@article {1395,
	title = {Exploiting the Nanoparticle Plasmon Effect: Observing Drug Delivery Dynamics in Single Cells via Raman/Fluorescence Imaging Spectroscopy},
	journal = {Acs Nano},
	volume = {7},
	number = {8},
	year = {2013},
	note = {Kang, Bin Afifi, Marwa M. Austin, Lauren A. El-Sayed, Mostafa A.},
	month = {Aug},
	pages = {7420-7427},
	isbn = {1936-0851},
	doi = {10.1021/nn403351z},
	author = {Kang, B. and Afifi, M. M. and Austin, Lauren and El-Sayed, M. A.}
}
@article {1332,
	title = {Real-Time Molecular Imaging throughout the Entire Cell Cycle by Targeted Plasmonic-Enhanced Rayleigh/Raman Spectroscopy},
	journal = {Nano Letters},
	volume = {12},
	number = {10},
	year = {2012},
	note = {Times Cited: 0Kang, Bin Austin, Lauren A. El-Sayed, Mostafa A.},
	month = {Oct},
	pages = {5369-5375},
	abstract = {Due to their strong enhancement of scattered light, plasmonic nanoparticles have been utilized for various biological and medical applications. Here, we describe a new technique, Targeted Plasmonic-Enhanced Single-Cell Rayleigh/Raman Spectroscopy, to monitor the molecular changes of any cell-component, such as the nucleus, during the different phases of its full cell cycle by simultaneously recording its Rayleigh images and Raman vibration spectra in real-time. The analysis of the observed Raman DNA and protein peaks allowed the different phases of the cell cycle to be identified. This technique could be used for disease diagnostics and potentially improve our understanding of the molecular mechanisms of cellular functions such as division, death, signaling, and drug action.},
	isbn = {1530-6984},
	doi = {10.1021/nl3027586},
	author = {Kang, B. and Austin, Lauren and El-Sayed, M. A.}
}
@article {1325,
	title = {Plasmonic Imaging of Human Oral Cancer Cell Communities during Programmed Cell Death by Nuclear-Targeting Silver Nanoparticles},
	journal = {Journal of the American Chemical Society},
	volume = {133},
	number = {44},
	year = {2011},
	note = {Times Cited: 13Austin, Lauren A. Kang, Bin Yen, Chun-Wan El-Sayed, Mostafa A.},
	month = {Nov},
	pages = {17594-17597},
	abstract = {Plasmonic nanoparticles (NPs) have become a useful platform in Medicine for potential uses in disease diagnosis and treatment. Recently, it has been reported that plasmonic NPs conjugated to nuclear targeting peptides cause DNA damage and apoptotic populations in cancer cells. In the present work, we utilized the plasmonic scattering property and the ability of nuclear-targeted silver nanoparticles (NLS/RGD-AgNPs) to induce programmed cell death in order to image in real-time the behavior of human oral squamous carcinoma (HSC-3) cell communities during and after the induction of apoptosis. Plasmonic live-cell imaging revealed that HSC-3 cells behave as nonprofessional phagocytes. The induction of apoptosis in some cells led to attraction of and their subsequent engulfment by neighboring cells. Attraction to apoptotic cells resulted in clustering of the cellular community. Live-cell imaging also revealed that,. as the initial,concentration of NLS/RGD-AgNPs. increases, the rate of self killing increases and the degree of attraction and clustering decreases. These results are discussed in terms of the proposed mechanism of cells undergoing programmed cell death.},
	isbn = {0002-7863},
	doi = {10.1021/ja207807t},
	author = {Austin, Lauren and Kang, B. and Yen, C. W. and El-Sayed, M. A.}
}
