@article {1361,
	title = {The Most Effective Gold Nanorod Size for Plasmonic Photothermal Therapy: Theory and In Vitro Experiments},
	journal = {Journal of Physical Chemistry B},
	volume = {118},
	number = {5},
	year = {2014},
	note = {Mackey, Megan A. Ali, Moustafa R. K. Austin, Lauren A. Near, Rachel D. El-Sayed, Mostafa A.},
	month = {Feb},
	pages = {1319-1326},
	isbn = {1520-6106},
	doi = {10.1021/jp409298f},
	author = {Mackey, M. A. and Ali, M. R. K. and Austin, Lauren and Near, R. D. and El-Sayed, M. A.}
}
@article {1373,
	title = {XAV939: From a Small Inhibitor to a Potent Drug Bioconjugate When Delivered by Gold Nanoparticles},
	journal = {Bioconjugate Chemistry},
	volume = {25},
	number = {2},
	year = {2014},
	note = {Afifi, Marwa M. Austin, Lauren A. Mackey, Megan A. El-Sayed, Mostafa A.},
	month = {Feb},
	pages = {207-215},
	isbn = {1043-1802},
	doi = {10.1021/bc400271x},
	author = {Afifi, M. M. and Austin, Lauren and Mackey, M. A. and El-Sayed, M. A.}
}
@article {1392,
	title = {Inducing Cancer Cell Death by Targeting Its Nucleus: Solid Gold Nanospheres versus Hollow Gold Nanocages},
	journal = {Bioconjugate Chemistry},
	volume = {24},
	number = {6},
	year = {2013},
	note = {Mackey, Megan A. Saira, Farhat Mahmoud, Mahmoud A. El-Sayed, Mostafa A.},
	month = {Jun},
	pages = {897-906},
	isbn = {1043-1802},
	doi = {10.1021/bc300592d},
	author = {Mackey, M. A. and Saira, F. and Mahmoud, M A and El-Sayed, M. A.}
}
@article {1378,
	title = {Surface-Enhanced Raman Spectroscopy for Real-Time Monitoring of Reactive Oxygen Species-Induced DNA Damage and Its Prevention by Platinum Nanoparticles},
	journal = {Acs Nano},
	volume = {7},
	number = {9},
	year = {2013},
	note = {Panikkanvalappil, Sajanlal R. Mahmoud, Mahmoud A. Mackey, Megan A. El-Sayed, Mostafa A.},
	month = {Sep},
	pages = {7524-7533},
	isbn = {1936-0851},
	doi = {10.1021/nn403722x},
	author = {Panikkanvalappil, S. R. and Mahmoud, M A and Mackey, M. A. and El-Sayed, M. A.}
}
@article {1088,
	title = {Remote Triggered Release of Doxorubicin in Tumors by Synergistic Application of Thermosensitive Liposomes and Gold Nanorods},
	journal = {Acs Nano},
	volume = {5},
	number = {6},
	year = {2011},
	note = {Agarwal, Abhiruchi Mackey, Megan A. El-Sayed, Mostafa A. Bellamkonda, Ravi V.},
	month = {Jun},
	pages = {4919-4926},
	abstract = {Delivery cif chemotherapeutic agents after encapsulation in nanocarriers such as liposomes diminishes side-effects, as PEGylated nanocarrier pharmacokinetics decrease dosing to healthy tissues and accumulate in tumors due to the enhanced permeability and retention effect. Once in the tumor, however, dosing of the chemotherapeutic to tumor cells is limited potentially by the rate of release from the carriers and the size-constrained, poor diffusivity of nanocarriers in tumor interstitium. Here, we report the design and fabrication of a thermosensitive liposomal nanocarder that maintains its encapsulation stability with a high concentration of doxorubicin payload, thereby minimizing "leak" and attendant toxicity. When used synergistically with PEGylated gold nanorods and near-infrared stimulation, remote triggered release of doxorubicin from thermosensitive liposomes was achieved in a mouse tumor model of human glioblastoma (U87), resulting in a. significant increase in efficacy when compared to nontriggered or nonthermosensitive PEGylated liposomes. This enhancement in efficacy is attributed to increase in tumor-site apoptosis, as was evident from noninvasive apoptosis imaging using Annexin-Vivo 750 probe. This strategy afford; remotely triggered control of tumor dosing of nanocarrier-encapsulated doxorubicin without sacrificing the ability to differentially dose drugs to tumors via the enhanced permeation and retention effect.},
	isbn = {1936-0851},
	doi = {10.1021/nn201010q},
	author = {Agarwal, A. and Mackey, M. A. and El-Sayed, Mostafa A and Bellamkonda, R. V.}
}
@article {1097,
	title = {Comparative study of photothermolysis of cancer cells with nuclear-targeted or cytoplasm-targeted gold nanospheres: continuous wave or pulsed lasers},
	journal = {Journal of Biomedical Optics},
	volume = {15},
	number = {5},
	year = {2010},
	note = {Huang, Xiaohua Kang, Bin Qian, Wei Mackey, Megan A. Chen, Po C. Oyelere, Adegboyega K. El-Sayed, Ivan H. El-Sayed, Mostafa A.},
	month = {Sep-Oct},
	abstract = {We conduct a comparative study on the efficiency and cell death pathways of continuous wave (cw) and nanosecond pulsed laser photothermal cancer therapy using gold nanospheres delivered to either the cytoplasm or nucleus of cancer cells. Cytoplasm localization is achieved using arginine-glycine-aspartate peptide modified gold nanospheres, which target integrin receptors on the cell surface and are subsequently internalized by the cells. Nuclear delivery is achieved by conjugating the gold nanospheres with nuclear localization sequence peptides originating from the simian virus. Photothermal experiments show that cell death can be induced with a single pulse of a nanosecond laser more efficiently than with a cw laser. When the cw laser is applied, gold nanospheres localized in the cytoplasm are more effective in inducing cell destruction than gold nanospheres localized at the nucleus. The opposite effect is observed when the nanosecond pulsed laser is used, suggesting that plasmonic field enhancement of the nonlinear absorption processes occurs at high localization of gold nanospheres at the nucleus. Cell death pathways are further investigated via a standard apoptosis kit to show that the cell death mechanisms depend on the type of laser used. While the cw laser induces cell death via apoptosis, the nanosecond pulsed laser leads to cell necrosis. These studies add mechanistic insight to gold nanoparticle-based photothermal therapy of cancer. (c) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3486538]},
	isbn = {1083-3668},
	doi = {10.1117/1.3486538},
	author = {Huang, Xiaohua and Kang, Bin and Qian, Wei and Mackey, M. A. and Chen, P. C. and Oyelere, A. K. and El Sayed, I.H. and El-Sayed, Mostafa A}
}
