@article {1361,
	title = {The Most Effective Gold Nanorod Size for Plasmonic Photothermal Therapy: Theory and In Vitro Experiments},
	journal = {Journal of Physical Chemistry B},
	volume = {118},
	number = {5},
	year = {2014},
	note = {Mackey, Megan A. Ali, Moustafa R. K. Austin, Lauren A. Near, Rachel D. El-Sayed, Mostafa A.},
	month = {Feb},
	pages = {1319-1326},
	isbn = {1520-6106},
	doi = {10.1021/jp409298f},
	author = {Mackey, M. A. and Ali, M. R. K. and Austin, Lauren and Near, R. D. and El-Sayed, M. A.}
}
@article {1365,
	title = {Observing Real-Time Molecular Event Dynamics of Apoptosis in Living Cancer Cells using Nuclear-Targeted Plasmonically Enhanced Raman Nanoprobes},
	journal = {ACS nano},
	volume = {8},
	number = {5},
	year = {2014},
	pages = {4883-4892},
	isbn = {1936-0851},
	author = {Kang, Bin and Austin, Lauren and El-Sayed, Mostafa A.}
}
@article {1369,
	title = {The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery},
	journal = {Archives of Toxicology},
	year = {2014},
	pages = {1-27},
	isbn = {0340-5761},
	author = {Austin, Lauren and Mackey, Megan A. and Dreaden, Erik C. and El-Sayed, Mostafa A.}
}
@article {1368,
	title = {P-Glycoprotein-Dependent Trafficking of Nanoparticle-Drug Conjugates},
	journal = {Small},
	volume = {10},
	number = {9},
	year = {2014},
	pages = {1719-1723},
	isbn = {1613-6829},
	author = {Dreaden, Erik C. and Raji, Idris O and Austin, Lauren and Fathi, Shaghayegh and Mwakwari, Sandra C and Humphries, William H and Kang, Bin and Oyelere, Adegboyega K and El-Sayed, Mostafa A}
}
@article {1373,
	title = {XAV939: From a Small Inhibitor to a Potent Drug Bioconjugate When Delivered by Gold Nanoparticles},
	journal = {Bioconjugate Chemistry},
	volume = {25},
	number = {2},
	year = {2014},
	note = {Afifi, Marwa M. Austin, Lauren A. Mackey, Megan A. El-Sayed, Mostafa A.},
	month = {Feb},
	pages = {207-215},
	isbn = {1043-1802},
	doi = {10.1021/bc400271x},
	author = {Afifi, M. M. and Austin, Lauren and Mackey, M. A. and El-Sayed, M. A.}
}
@article {1395,
	title = {Exploiting the Nanoparticle Plasmon Effect: Observing Drug Delivery Dynamics in Single Cells via Raman/Fluorescence Imaging Spectroscopy},
	journal = {Acs Nano},
	volume = {7},
	number = {8},
	year = {2013},
	note = {Kang, Bin Afifi, Marwa M. Austin, Lauren A. El-Sayed, Mostafa A.},
	month = {Aug},
	pages = {7420-7427},
	isbn = {1936-0851},
	doi = {10.1021/nn403351z},
	author = {Kang, B. and Afifi, M. M. and Austin, Lauren and El-Sayed, M. A.}
}
@article {1347,
	title = {A New Nanotechnology Technique for Determining Drug Efficacy Using Targeted Plasmonically Enhanced Single Cell Imaging Spectroscopy},
	journal = {J Am Chem Soc},
	year = {2013},
	note = {MEDLINE AN 2013441929(Journal; Article; (JOURNAL ARTICLE))},
	month = {//},
	abstract = {Recently, we described a new technique, targeted plasmonically enhanced single cell imaging spectroscopy (T-PESCIS), which exploits the plasmonic properties of gold nanoparticles, e.g. gold nanospheres, to simultaneously obtain enhanced intracellular Raman molecular spectra and enhanced Rayleigh cell scattering images throughout the entire span of a single cell cycle. In the present work, we demonstrate the use of T-PESCIS in evaluating the relative efficacy and dynamics of two popular chemotherapy drugs on human oral squamous carcinoma (HSC-3) cells. T-PESCIS revealed three plasmonically enhanced Raman scattering vibration bands, 500, 1000, and 1585 cm(-1), associated with the cellular death dynamics. Detailed analysis indicated that the decrease in the 500 cm(-1) band did not correlate well with drug efficacy but could indicate death initiation. The time it takes for the relative intensity of either the 1000 or 1585 cm(-1) band ("SERS death" bands) to appear and increase to its maximum value after the injection of a known concentration of the drug can be related to the drug{\textquoteright}s efficacy. The inverse ratio, termed cell death enhancement factor, of these characteristic death times when using either band, especially the spectrally sharp band at 1000 cm(-1), gave the correct drug efficacy ratio as determined by the commonly used XTT cell viability assay method. These results strongly suggest the potential future use of this technique in determining the efficacy, dynamics, and molecular mechanisms of various drugs against different diseases.[on SciFinder (R)]},
	isbn = {1520-5126},
	author = {Austin, Lauren and Kang, Bin and El-Sayed, Mostafa A.}
}
@article {1396,
	title = {Plasmonic enhancement of photodynamic cancer therapy},
	journal = {Journal of Photochemistry and Photobiology a-Chemistry},
	volume = {269},
	year = {2013},
	note = {Hayden, Steven C. Austin, Lauren A. Near, Rachel D. Ozturk, Ramazan El-Sayed, Mostafa A.},
	month = {Oct},
	pages = {34-41},
	isbn = {1010-6030},
	doi = {10.1016/j.jphotochem.2013.06.004},
	author = {Hayden, S. C. and Austin, Lauren and Near, R. D. and Ozturk, R. and El-Sayed, M. A.}
}
@proceedings {1377,
	title = {Toxicities and antitumor efficacy of tumor-targeted AuNRs in mouse model},
	volume = {73},
	number = {8},
	year = {2013},
	publisher = {AMER ASSOC CANCER RESEARCH 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA},
	isbn = {0008-5472},
	author = {Peng, Xianghong and Mackey, Megan and Austin, Lauren and Oyelere, Adegboyega and Chen, Georgia and Huang, Xiaohua and El-Sayed, Mostafa A. and Shin, Dong M}
}
@article {1329,
	title = {Antiandrogen Gold Nanoparticles Dual-Target and Overcome Treatment Resistance in Hormone-Insensitive Prostate Cancer Cells},
	journal = {Bioconjugate Chemistry},
	volume = {23},
	number = {8},
	year = {2012},
	note = {Times Cited: 0Dreaden, Erik C. Gryder, Berkley E. Austin, Lauren A. Defo, Brice A. Tene Hayden, Steven C. Pi, Min Quarles, L. Darryl Oyelere, Adegboyega K. El-Sayed, Mostafa A.},
	month = {Aug},
	pages = {1507-1512},
	abstract = {prostate cancer is the most commonly diagnosed cancer among men in the developed countries.(1) One in six males in the U.S.(2) and one in nine males in the U.K.(3) will develop the disease at some point during their lifetime. Despite advances in prostate cancer screening, more than a quarter of a million men die from the disease every year(1) due primarily to treatment-resistance and metastasis. Colloidal nanotechnologies can provide tremendous enhancements to existing targeting/treatment strategies for prostate cancer to which malignant cells are less sensitive. Here, we show that antiandrogen gold nanoparticles-multivalent analogues of antiandrogens currently used in clinical therapy for prostate cancer-selectively engage two distinct receptors, androgen receptor (AR), a target for the treatment of prostate cancer, as well as a novel G-protein coupled receptor, GPRC6A, that is also upregulated in prostate cancer. These nanoparticles selectively accumulated in hormone-insensitive and chemotherapy resistant prostate cancer cells, bound androgen receptor with multivalent affinity, and exhibited greatly enhanced drug potency versus monovalent antiandrogens currently in clinical use Further, antiandrogen gold nanoparticles selectively stimulated GPRC6A with multivalent affinity, demonstrating that the delivery of nanoscale antiandrogens can also be facilitated by the transmembrane receptor in order to realize increasingly selective, increasingly potent therapy for treatment-resistant prostate cancers.},
	isbn = {1043-1802},
	doi = {10.1021/bc300158k},
	author = {Dreaden, E. C. and Gryder, B. E. and Austin, Lauren and Defo, B. A. T. and Hayden, S. C. and Pi, M. and Quarles, L. D. and Oyelere, A. K. and El-Sayed, M. A.}
}
@article {1332,
	title = {Real-Time Molecular Imaging throughout the Entire Cell Cycle by Targeted Plasmonic-Enhanced Rayleigh/Raman Spectroscopy},
	journal = {Nano Letters},
	volume = {12},
	number = {10},
	year = {2012},
	note = {Times Cited: 0Kang, Bin Austin, Lauren A. El-Sayed, Mostafa A.},
	month = {Oct},
	pages = {5369-5375},
	abstract = {Due to their strong enhancement of scattered light, plasmonic nanoparticles have been utilized for various biological and medical applications. Here, we describe a new technique, Targeted Plasmonic-Enhanced Single-Cell Rayleigh/Raman Spectroscopy, to monitor the molecular changes of any cell-component, such as the nucleus, during the different phases of its full cell cycle by simultaneously recording its Rayleigh images and Raman vibration spectra in real-time. The analysis of the observed Raman DNA and protein peaks allowed the different phases of the cell cycle to be identified. This technique could be used for disease diagnostics and potentially improve our understanding of the molecular mechanisms of cellular functions such as division, death, signaling, and drug action.},
	isbn = {1530-6984},
	doi = {10.1021/nl3027586},
	author = {Kang, B. and Austin, Lauren and El-Sayed, M. A.}
}
@article {1327,
	title = {Size matters: gold nanoparticles in targeted cancer drug delivery},
	journal = {Ther. Delivery},
	volume = {3},
	number = {4},
	year = {2012},
	note = {CAPLUS AN 2012:489934(Journal; General Review; Online Computer File)},
	month = {//},
	pages = {457-478},
	publisher = {Future Science Ltd.},
	type = {10.4155/tde.12.21},
	abstract = {A review. Cancer is the current leading cause of death worldwide, responsible for approx. one quarter of all deaths in the USA and UK. Nanotechnologies provide tremendous opportunities for multimodal, site-specific drug delivery to these disease sites and Au nanoparticles further offer a particularly unique set of phys., chem. and photonic properties with which to do so. This review will highlight some recent advances, by our lab. and others, in the use of Au nanoparticles for systemic drug delivery to these malignancies and will also provide insights into their rational design, synthesis, physiol. properties and clin./preclin. applications, as well as strategies and challenges toward the clin. implementation of these constructs moving forward. [on SciFinder(R)]},
	keywords = {review gold nanoparticle targeted cancer drug delivery},
	isbn = {2041-5990},
	doi = {10.4155/tde.12.21},
	author = {Dreaden, Erik C. and Austin, Lauren and Mackey, Megan A. and El-Sayed, Mostafa A.}
}
@article {1330,
	title = {Small Molecule-Gold Nanorod Conjugates Selectively Target and Induce Macrophage Cytotoxicity towards Breast Cancer Cells},
	journal = {Small},
	volume = {8},
	number = {18},
	year = {2012},
	note = {Times Cited: 0Dreaden, Erik C. Mwakwari, Sandra C. Austin, Lauren A. Kieffer, Matthew J. Oyelere, Adegboyega K. El-Sayed, Mostafa A.},
	month = {Sep},
	pages = {2819-2822},
	isbn = {1613-6810},
	doi = {10.1002/smll.201200333},
	author = {Dreaden, E. C. and Mwakwari, S. C. and Austin, Lauren and Kieffer, M. J. and Oyelere, A. K. and El-Sayed, M. A.}
}
@article {1325,
	title = {Plasmonic Imaging of Human Oral Cancer Cell Communities during Programmed Cell Death by Nuclear-Targeting Silver Nanoparticles},
	journal = {Journal of the American Chemical Society},
	volume = {133},
	number = {44},
	year = {2011},
	note = {Times Cited: 13Austin, Lauren A. Kang, Bin Yen, Chun-Wan El-Sayed, Mostafa A.},
	month = {Nov},
	pages = {17594-17597},
	abstract = {Plasmonic nanoparticles (NPs) have become a useful platform in Medicine for potential uses in disease diagnosis and treatment. Recently, it has been reported that plasmonic NPs conjugated to nuclear targeting peptides cause DNA damage and apoptotic populations in cancer cells. In the present work, we utilized the plasmonic scattering property and the ability of nuclear-targeted silver nanoparticles (NLS/RGD-AgNPs) to induce programmed cell death in order to image in real-time the behavior of human oral squamous carcinoma (HSC-3) cell communities during and after the induction of apoptosis. Plasmonic live-cell imaging revealed that HSC-3 cells behave as nonprofessional phagocytes. The induction of apoptosis in some cells led to attraction of and their subsequent engulfment by neighboring cells. Attraction to apoptotic cells resulted in clustering of the cellular community. Live-cell imaging also revealed that,. as the initial,concentration of NLS/RGD-AgNPs. increases, the rate of self killing increases and the degree of attraction and clustering decreases. These results are discussed in terms of the proposed mechanism of cells undergoing programmed cell death.},
	isbn = {0002-7863},
	doi = {10.1021/ja207807t},
	author = {Austin, Lauren and Kang, B. and Yen, C. W. and El-Sayed, M. A.}
}
