TY - JOUR T1 - Real-Time Molecular Imaging throughout the Entire Cell Cycle by Targeted Plasmonic-Enhanced Rayleigh/Raman Spectroscopy JF - Nano Letters Y1 - 2012 A1 - Kang, B. A1 - Austin, Lauren A1 - El-Sayed, M. A. AB - Due to their strong enhancement of scattered light, plasmonic nanoparticles have been utilized for various biological and medical applications. Here, we describe a new technique, Targeted Plasmonic-Enhanced Single-Cell Rayleigh/Raman Spectroscopy, to monitor the molecular changes of any cell-component, such as the nucleus, during the different phases of its full cell cycle by simultaneously recording its Rayleigh images and Raman vibration spectra in real-time. The analysis of the observed Raman DNA and protein peaks allowed the different phases of the cell cycle to be identified. This technique could be used for disease diagnostics and potentially improve our understanding of the molecular mechanisms of cellular functions such as division, death, signaling, and drug action. VL - 12 SN - 1530-6984 N1 - Times Cited: 0Kang, Bin Austin, Lauren A. El-Sayed, Mostafa A. M3 - 10.1021/nl3027586 ER -