The following research projects are carried out in the Laser Dynamics Laboratory (LDL) directed by Professor El-Sayed (http://ldl.gatech.edu
). LDL houses the most recent lasers and laser spectroscopic equipment for time resolved optical, Raman and IR studies. It also houses biochemical labs equipped with cell culture facilities, modern facilities of plasmonic imaging in time the single cells and their contents using either SERS spectra or Rayleigh images during the cell full life (between birth to division) or as it dies. Available for LDL researchers the use of the Georgia Tech clean room facilities with its High resolution TEM, electron-beam facilities for the synthesis of nanoparticles of different shapes, and its high resolution structural determination facilities.
The present research interests are focused on the synthesis, the determination of the structure and the properties of materials (semiconductor and metallic nanoparticles) of sizes confined to the nanoscale (between one and 100 nm). Applications in different technical fields ranging from nanpcatalysis, nanosensors to cancer nano medicine and moleculat cell-biology were developped and used.
Over the past twenty years, El-Sayed and his group have made unparalleled contributions to the fields of nanoscience and nanotechnology . Figure1 below (taken in July of 2014 from Google Scholar citation): http://scholar.google.com/citations?user=BMpDLscAAAAJ&hl=en
) shows the dramatic change in the annual number of citations with time of the published papers by his group before and after changing his research activity to the nanoscience field (in the mid-ninety). It also shows the large change in his h-index in the last five years, when the impact of focusing his nano-science research on nano-medicine and cancer research (the developing different techniques using gold and silver nanoparticles in the diagnosis, therapy and studying on single cell of cancer).
Fig 1. The annual number of citations to El-Sayed’s group publications before and after getting into the nanoscience research in the late nineties until mid of 2014(Scholar.google.com/citations).
Fig 2. El-Sayed’s group annual publications in the nanoscience research field until mid July of 2014.
He and his group have published more than 670 articles total by the mid of 2014 with half of this appeard in the last twenty years (The number of citations per paper published in the past few years has been in the hundreds (See the large exponential increase in the citations to his research papers in this period in fig1 and the number of published papers in fig 2).
LDL research laboratory has been consistently ranked among the top chemical research laboratories in the world during the last decade (#4 among Academic laboratories according to the Times Higher Education and #17, among Academic, national, international and industrial laboratories as concluded by Thomson-Reuters: Refer to his website: http://ldl.gatech.edu). Figure 2 also shows the large increase in the # of his annual published papers reached 27 papers in 2013 and extrapolated to over 30 papers in 2014. It is this excellent scientific creative performance as well as the research field that El-Sayed selected to do his reasearch that were responsible for crowning him with the highest national honor a scientist in the USA can receive, this is the USA National Medal of Science ( in chemistry) :nanoscience: nanocatalysis, and nanomedicine (please go to: http://ldl.gatech.edu.)
Early studies in LDL in this field included the unique optical and photo-thermal properties of gold and silver nanoparticles of different and discussed the potential use could be used to more easily Nano-science (e.g. in1,2,3,4,5,6) that lead to the rapid development of this important field and some of its potential applications in the field of nanotechnology, e.g. in catalysis, in sensors and in the important field of medicine. This is the reason for the very high citations to his work. During the past five years alone, LDL publications have received 37,880 citations. : http://scholar.google.com/citations?user=BMpDLscAAAAJ&hl=en
On Jan. 29, 2010 - the Laser Dynamics Laboratory (LDL) ( see http://ldl.gatech.edu/), whose director is Professor El-Sayed, was ranked #4 Worldwide among Academic chemistry research labs of the past decade by the Times Higher Education. LDL publications garnered an impressive 75.74 citations per paper over this period. On March 21, 2011, the Laser Dynamics Laboratory was ranked #17 worldwide among all chemistry research labs (Academic, National as well as the Industrial labs) during the past decade (2000-2010) by the Thomson Reuters. During this period. LDL published more highly cited manuscripts than any others in the top 20.
Below we will describe some of the LDL to nanoscience and its important impact on technology. Three fields this group has studied and obseved new nano-scientific properties with some are shown to have important impact on the field of Nanotechnology.
1. C Burda, X Chen, R Narayanan, MA El-Sayed, Chemistry and properties of nanocrystals of different shapes, Chemical reviews 105 (4), 1025-1102, 2005 (invited, 4400 citations)
2. S Link, MA El-Sayed, Spectral properties and relaxation dynamics of surface plasmon electronic oscillations in gold and silver nanodots and nanorods,, The Journal of Physical Chemistry B 103 (40), 8410-8426 (1999) (Invited, 2507 citations)
3.MA El-Sayed, Some interesting properties of metals confined in time and nanometer space of different shapes, Accounts of Chemical Research 34 (4), 257-264,2001 INVITED (2080 citations).
4. .S Link, MA El-Sayed, Shape and size dependence of radiative, non-radiative and photothermal properties of gold nanocrystals, International Reviews in Physical Chemistry 19 (3), 409-453 (Invited, 1330 citations)
5. Shape-controlled synthesis of colloidal platinum nanoparticles, TS Ahmadi, ZL Wang, TC Green, A Henglein, MA El-Sayed, SCIENCE-1924-1925, 1996 (2013 citations).
6. P. K. Jain, X. H. Huang, I. H. El-Sayed and M. A. El-Sayed. (2008) Noble Metals on the Nanoscale: Optical and Photothermal Properties and Some Applications in Imaging, Sensing, Biology, and Medicine. Accounts of Chemical Research 41, 1578-1586. (Invited, 1221 citations)
7. IH El-Sayed, X Huang, MA El-Sayed, Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer,Nano letters (5), 829-834, (1120 citations, The most cited paper in the Journal of the American Chemical Society in the whole year)