%0 Journal Article %J Journal of Photochemistry and Photobiology a-Chemistry %D 2013 %T Plasmonic enhancement of photodynamic cancer therapy %A Hayden, S. C. %A Austin, Lauren %A Near, R. D. %A Ozturk, R. %A El-Sayed, M. A. %B Journal of Photochemistry and Photobiology a-Chemistry %V 269 %P 34-41 %8 Oct %@ 1010-6030 %G eng %M WOS:000324454900005 %R 10.1016/j.jphotochem.2013.06.004 %0 Journal Article %J Journal of Physical Chemistry C %D 2013 %T Rapid and Efficient Prediction of Optical Extinction Coefficients for Gold Nanospheres and Gold Nanorods %A Near, R. D. %A Hayden, S. C. %A Hunter, R. E. %A Thackston, D. %A El-Sayed, M. A. %B Journal of Physical Chemistry C %V 117 %P 23950-23955 %8 Nov %@ 1932-7447 %G eng %M WOS:000327110500056 %! J. Phys. Chem. C %R 10.1021/jp4082596 %0 Journal Article %J Journal of Physical Chemistry C %D 2013 %T Thin to Thick, Short to Long: Spectral Properties of Gold Nanorods by Theoretical Modeling %A Near, R. D. %A Hayden, S. C. %A El-Sayed, M. A. %B Journal of Physical Chemistry C %V 117 %P 18653-18656 %8 Sep %@ 1932-7447 %G eng %M WOS:000330162700044 %! J. Phys. Chem. C %R 10.1021/jp4078344 %0 Journal Article %J Journal of the American Chemical Society %D 2012 %T Aggregation and Interaction of Cationic Nanoparticles on Bacterial Surfaces %A Hayden, S. C. %A Zhao, G. X. %A Saha, K. %A Phillips, R. L. %A Li, X. N. %A Miranda, O. R. %A Rotello, V. M. %A El-Sayed, M. A. %A Schmidt-Krey, I. %A Bunz, U. H. F. %X Cationic monolayer-protected gold nanoparticles (AuNPs) with sizes of 6 or 2 nm interact with the cell membranes of Escherichia coli (Gram-) and Bacillus subtilis (Gram+), resulting in the formation of strikingly distinct AuNP surface aggregation patterns or lysis depending upon the size of the AuNPs. The aggregation phenomena were investigated by transmission electron microscopy and UV-vis spectroscopy. Upon proteolytic treatment of the bacteria, the distinct aggregation patterns disappeared. %B Journal of the American Chemical Society %V 134 %P 6920-6923 %8 Apr %@ 0002-7863 %G eng %M WOS:000303139800009 %R 10.1021/ja301167y %0 Journal Article %J Bioconjugate Chemistry %D 2012 %T Antiandrogen Gold Nanoparticles Dual-Target and Overcome Treatment Resistance in Hormone-Insensitive Prostate Cancer Cells %A Dreaden, E. C. %A Gryder, B. E. %A Austin, Lauren %A Defo, B. A. T. %A Hayden, S. C. %A Pi, M. %A Quarles, L. D. %A Oyelere, A. K. %A El-Sayed, M. A. %X prostate cancer is the most commonly diagnosed cancer among men in the developed countries.(1) One in six males in the U.S.(2) and one in nine males in the U.K.(3) will develop the disease at some point during their lifetime. Despite advances in prostate cancer screening, more than a quarter of a million men die from the disease every year(1) due primarily to treatment-resistance and metastasis. Colloidal nanotechnologies can provide tremendous enhancements to existing targeting/treatment strategies for prostate cancer to which malignant cells are less sensitive. Here, we show that antiandrogen gold nanoparticles-multivalent analogues of antiandrogens currently used in clinical therapy for prostate cancer-selectively engage two distinct receptors, androgen receptor (AR), a target for the treatment of prostate cancer, as well as a novel G-protein coupled receptor, GPRC6A, that is also upregulated in prostate cancer. These nanoparticles selectively accumulated in hormone-insensitive and chemotherapy resistant prostate cancer cells, bound androgen receptor with multivalent affinity, and exhibited greatly enhanced drug potency versus monovalent antiandrogens currently in clinical use Further, antiandrogen gold nanoparticles selectively stimulated GPRC6A with multivalent affinity, demonstrating that the delivery of nanoscale antiandrogens can also be facilitated by the transmembrane receptor in order to realize increasingly selective, increasingly potent therapy for treatment-resistant prostate cancers. %B Bioconjugate Chemistry %V 23 %P 1507-1512 %8 Aug %@ 1043-1802 %G eng %M WOS:000307487300002 %R 10.1021/bc300158k %0 Journal Article %J Nano Letters %D 2011 %T Tailoring Plasmonic and Electrostatic Field Effects To Maximize Solar Energy Conversion by Bacteriorhodopsin, the Other Natural Photosynthetic System %A Yen, C. W. %A Hayden, S. C. %A Dreaden, Erik %A Szymanski, P. %A El-Sayed, Mostafa A %X We have explored the plasmonic field enhancement of current production from bacteriorhodopsin (bR) by maximizing the blue light effect, where the influx of blue photons absorbed by the long-lived M intermediate drastically shortens the time scale of the bR photocycle, leading to current enhancement. To this end, we used three approaches in our solution-based cell: proton selective Nafion membrane. (2) We maximized the plasmonic surface (1) We improved the charge carrier separation in solution through the use of a field effects by selecting the capping polymer with minimum surface field screening and best nanopartide stability. (3) We selected the plasmonic nanoparticle with the strongest plasmonic field whose surface plasmon resonance has the largest spectral overlap with the blue light absorbing M-intermediate. Theoretical models are used to explain experimental results, which show a 40 nm cuboidal nanoparticle capped with 55k PVP polymer to give the best photocurrent enhancement. Enhanced by this particle, bR in our Nafion membrane solution cell gave a photocurrent of 0.21 mu A/cm(3), which is 5000 times larger than the published results for thin film bR electrochemical cells even with an applied bias. Additional possible enhancements are proposed. %B Nano Letters %V 11 %P 3821-3826 %8 Sep %@ 1530-6984 %G eng %M WOS:000294790200054 %R 10.1021/nl2018959 %0 Journal Article %J Journal of the American Chemical Society %D 2010 %T TiO(2) Nanotube/CdS Hybrid Electrodes: Extraordinary Enhancement in the Inactivation of Escherichia coli %A Hayden, S. C. %A Allam, N. K. %A El-Sayed, Mostafa A %X Titanium dioxide nanotubes offer distinct advantages over films of the same material in the production of hydroxyl radicals and subsequent inactivation of Escherichia coli in wastewater. However, their visible light absorption capabilities are limited. Semiconducting nanocrystals of cadmium sulfide have been used to increase the sensitivity of TiO(2) nanotubes to visible light. A small applied potential, using CdS-coated TiO(2) nanotube arrays, allowed for total inactivation of E. call in hitherto record short time. %B Journal of the American Chemical Society %V 132 %P 14406-14408 %8 Oct %@ 0002-7863 %G eng %M WOS:000283276800030 %R 10.1021/ja107034z