<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hayden, S. C.</style></author><author><style face="normal" font="default" size="100%">Zhao, G. X.</style></author><author><style face="normal" font="default" size="100%">Saha, K.</style></author><author><style face="normal" font="default" size="100%">Phillips, R. L.</style></author><author><style face="normal" font="default" size="100%">Li, X. N.</style></author><author><style face="normal" font="default" size="100%">Miranda, O. R.</style></author><author><style face="normal" font="default" size="100%">Rotello, V. M.</style></author><author><style face="normal" font="default" size="100%">El-Sayed, M. A.</style></author><author><style face="normal" font="default" size="100%">Schmidt-Krey, I.</style></author><author><style face="normal" font="default" size="100%">Bunz, U. H. F.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Aggregation and Interaction of Cationic Nanoparticles on Bacterial Surfaces</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of the American Chemical Society</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Apr</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">16</style></number><volume><style face="normal" font="default" size="100%">134</style></volume><pages><style face="normal" font="default" size="100%">6920-6923</style></pages><isbn><style face="normal" font="default" size="100%">0002-7863</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Cationic monolayer-protected gold nanoparticles (AuNPs) with sizes of 6 or 2 nm interact with the cell membranes of Escherichia coli (Gram-) and Bacillus subtilis (Gram+), resulting in the formation of strikingly distinct AuNP surface aggregation patterns or lysis depending upon the size of the AuNPs. The aggregation phenomena were investigated by transmission electron microscopy and UV-vis spectroscopy. Upon proteolytic treatment of the bacteria, the distinct aggregation patterns disappeared.</style></abstract><accession-num><style face="normal" font="default" size="100%">WOS:000303139800009</style></accession-num><notes><style face="normal" font="default" size="100%">Times Cited: 1Hayden, Steven C. Zhao, Gengxiang Saha, Krishnendu Phillips, Ronnie L. Li, Xiaoning Miranda, Oscar R. Rotello, Vincent M. El-Sayed, Mostafa A. Schmidt-Krey, Ingeborg Bunz, Uwe H. F.</style></notes><electronic-resource-num><style face="normal" font="default" size="100%">10.1021/ja301167y</style></electronic-resource-num></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dreaden, E. C.</style></author><author><style face="normal" font="default" size="100%">Gryder, B. E.</style></author><author><style face="normal" font="default" size="100%">Austin, Lauren</style></author><author><style face="normal" font="default" size="100%">Defo, B. A. T.</style></author><author><style face="normal" font="default" size="100%">Hayden, S. C.</style></author><author><style face="normal" font="default" size="100%">Pi, M.</style></author><author><style face="normal" font="default" size="100%">Quarles, L. D.</style></author><author><style face="normal" font="default" size="100%">Oyelere, A. K.</style></author><author><style face="normal" font="default" size="100%">El-Sayed, M. A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiandrogen Gold Nanoparticles Dual-Target and Overcome Treatment Resistance in Hormone-Insensitive Prostate Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Bioconjugate Chemistry</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Aug</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">8</style></number><volume><style face="normal" font="default" size="100%">23</style></volume><pages><style face="normal" font="default" size="100%">1507-1512</style></pages><isbn><style face="normal" font="default" size="100%">1043-1802</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">prostate cancer is the most commonly diagnosed cancer among men in the developed countries.(1) One in six males in the U.S.(2) and one in nine males in the U.K.(3) will develop the disease at some point during their lifetime. Despite advances in prostate cancer screening, more than a quarter of a million men die from the disease every year(1) due primarily to treatment-resistance and metastasis. Colloidal nanotechnologies can provide tremendous enhancements to existing targeting/treatment strategies for prostate cancer to which malignant cells are less sensitive. Here, we show that antiandrogen gold nanoparticles-multivalent analogues of antiandrogens currently used in clinical therapy for prostate cancer-selectively engage two distinct receptors, androgen receptor (AR), a target for the treatment of prostate cancer, as well as a novel G-protein coupled receptor, GPRC6A, that is also upregulated in prostate cancer. These nanoparticles selectively accumulated in hormone-insensitive and chemotherapy resistant prostate cancer cells, bound androgen receptor with multivalent affinity, and exhibited greatly enhanced drug potency versus monovalent antiandrogens currently in clinical use Further, antiandrogen gold nanoparticles selectively stimulated GPRC6A with multivalent affinity, demonstrating that the delivery of nanoscale antiandrogens can also be facilitated by the transmembrane receptor in order to realize increasingly selective, increasingly potent therapy for treatment-resistant prostate cancers.</style></abstract><accession-num><style face="normal" font="default" size="100%">WOS:000307487300002</style></accession-num><notes><style face="normal" font="default" size="100%">Times Cited: 0Dreaden, Erik C. Gryder, Berkley E. Austin, Lauren A. Defo, Brice A. Tene Hayden, Steven C. Pi, Min Quarles, L. Darryl Oyelere, Adegboyega K. El-Sayed, Mostafa A.</style></notes><electronic-resource-num><style face="normal" font="default" size="100%">10.1021/bc300158k</style></electronic-resource-num></record></records></xml>