TY - JOUR T1 - Chemosensitization of Cancer Cells via Gold Nanoparticle‐Induced Cell Cycle Regulation JF - Photochemistry and photobiology Y1 - 2014 A1 - Mackey, Megan A. A1 - El‐Sayed, Mostafa A VL - 90 SN - 1751-1097 J1 - Photochem Photobiol ER - TY - JOUR T1 - The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery JF - Archives of Toxicology Y1 - 2014 A1 - Austin, Lauren A1 - Mackey, Megan A. A1 - Dreaden, Erik C. A1 - El-Sayed, Mostafa A. SN - 0340-5761 J1 - Arch. Toxicol. ER - TY - JOUR T1 - Probing the unique dehydration-induced structural modifications in cancer cell DNA using surface enhanced Raman spectroscopy JF - J Am Chem Soc Y1 - 2013 A1 - Panikkanvalappil, Sajanlal R. A1 - Mackey, Megan A. A1 - El-Sayed, Mostafa A. AB - Conformation-induced formation of a series of unique Raman marker bands in cancer cell DNA, upon dehydration, have been probed for the first time with the use of surface enhanced Raman spectroscopy (SERS). These bands are capable of distinguishing cancer cell DNA from healthy cell DNA. For this simple and label-free DNA detection approach, we used conventional spherical silver nanoparticles, at a high concentration, without any aggregating agents, which gave highly reproducible SERS spectra of DNA separated from various human cells irrespective of their highly complex compositions and sequences. The observed phenomenon is attributed to the change in the chemical environment due to the presence of nucleobase lesions in cancer cell DNA and subsequent variation in the nearby electronic cloud during the dehydration-driven conformational changes. Detailed analysis of the SERS spectra gives important insight about the lesion-induced structural modifications upon dehydration in the cancer cell DNA. These results have widespread implications in cancer diagnostics, where SERS provides vital information about the DNA modifications in the cancer cells.[on SciFinder (R)] SN - 1520-5126 N1 - MEDLINE AN 2013442001(Journal; Article; (JOURNAL ARTICLE)) ER - TY - JOUR T1 - Size matters: gold nanoparticles in targeted cancer drug delivery JF - Ther. Delivery Y1 - 2012 A1 - Dreaden, Erik C. A1 - Austin, Lauren A1 - Mackey, Megan A. A1 - El-Sayed, Mostafa A. KW - review gold nanoparticle targeted cancer drug delivery AB - A review. Cancer is the current leading cause of death worldwide, responsible for approx. one quarter of all deaths in the USA and UK. Nanotechnologies provide tremendous opportunities for multimodal, site-specific drug delivery to these disease sites and Au nanoparticles further offer a particularly unique set of phys., chem. and photonic properties with which to do so. This review will highlight some recent advances, by our lab. and others, in the use of Au nanoparticles for systemic drug delivery to these malignancies and will also provide insights into their rational design, synthesis, physiol. properties and clin./preclin. applications, as well as strategies and challenges toward the clin. implementation of these constructs moving forward. [on SciFinder(R)] PB - Future Science Ltd. VL - 3 SN - 2041-5990 N1 - CAPLUS AN 2012:489934(Journal; General Review; Online Computer File) M3 - 10.4155/tde.12.21 ER -