TY - JOUR T1 - Electrosynthesis of Ammonia Using Porous Bimetallic Pd–Ag Nanocatalysts in Liquid- and Gas-Phase Systems JF - ACS Catalysis Y1 - 2020 A1 - Nazemi, M. A1 - Ou, P. A1 - Alabbady, A. A1 - Soule, L. A1 - Liu, A. A1 - Song, J. A1 - Sulchek, T.A. A1 - Liu, M. A1 - El-Sayed, M. A. KW - display ER - TY - JOUR T1 - Gold Nanorod-Assisted Photothermal Therapy Decreases Bleeding during Breast Cancer Surgery in Dogs and Cats JF - Cancers Y1 - 2019 A1 - Ali, M.R. A1 - Farghali, H.A. A1 - Wu, Y. A1 - El-Sayed, I. A1 - Osman, A.H. A1 - Selim, S.A. A1 - El-Sayed, M.A. ER - TY - JOUR T1 - Photoexcited Surface Frustrated Lewis Pairs for Heterogeneous Photocatalytic Co2 Reduction JF - Am. Chem. Soc. Y1 - 2016 A1 - Ghuman, K. K. A1 - Hoch, L. B. A1 - Szymanski, P. A1 - Loh, J. Y. A1 - Kherani, N. P. A1 - El-Sayed, M. A. A1 - Ozin, G. A. A1 - Singh, C. V. ER - TY - JOUR T1 - Electronic and Vibrational Dynamics of Hollow Au Nanocages Embedded in Cu2O Shells JF - Photochemistry and Photobiology Y1 - 2015 A1 - Szymanski, Paul A1 - Mahmoud, Mahmoud A. A1 - O'Neil, Daniel A1 - Garlyyev, Batyr A1 - El-Sayed, Mostafa A. VL - 91 UR - http://dx.doi.org/10.1111/php.12432 M3 - 10.1111/php.12432 ER - TY - JOUR T1 - Near-Infrared Asymmetrical Squaraine Sensitizers for Highly Efficient Dye Sensitized Solar Cells: The Effect of π-Bridges and Anchoring Groups on Solar Cell Performance JF - Chemistry of Materials Y1 - 2015 A1 - Fadi M. Jradi A1 - Xiongwu Kang A1 - O’Neil, Daniel A1 - Gabriel Pajares A1 - Yulia A. Getmanenko A1 - Szymanski, Paul A1 - Timothy C. Parker A1 - El-Sayed, Mostafa A. A1 - Seth R. Marder VL - 27 UR - http://dx.doi.org/10.1021/cm5045946 M3 - 10.1021/cm5045946 ER - TY - JOUR T1 - Hollow and Solid Metallic Nanoparticles in Sensing and in Nanocatalysis JF - Chemistry of Materials Y1 - 2014 A1 - Mahmoud, M A A1 - O'Neil, D. A1 - El-Sayed, M. A. KW - n/a VL - 26 SN - 0897-4756 N1 - Mahmoud, Mahmoud A. O'Neil, Daniel El-Sayed, Mostafa A.Si J1 - Chem Mater M3 - 10.1021/cm4020892 ER - TY - JOUR T1 - P‐Glycoprotein‐Dependent Trafficking of Nanoparticle‐Drug Conjugates JF - Small Y1 - 2014 A1 - Dreaden, Erik C. A1 - Raji, Idris O A1 - Austin, Lauren A1 - Fathi, Shaghayegh A1 - Mwakwari, Sandra C A1 - Humphries, William H A1 - Kang, Bin A1 - Oyelere, Adegboyega K A1 - El‐Sayed, Mostafa A VL - 10 SN - 1613-6829 ER - TY - JOUR T1 - Shape- and Symmetry-Dependent Mechanical Properties of Metallic Gold and Silver on the Nanoscale JF - Nano Letters Y1 - 2014 A1 - Mahmoud, M A A1 - O'Neil, D. A1 - El-Sayed, M. A. VL - 14 SN - 1530-6984 N1 - Mahmoud, Mahmoud A. O'Neil, Daniel El-Sayed, Mostafa A. J1 - Nano Lett. M3 - 10.1021/nl4040362 ER - TY - JOUR T1 - The Spectroscopy of Homo and Heterodimers of Silver and Gold Nanocubes as a Function of Separation: a DDA Simulation JF - The Journal of Physical Chemistry A Y1 - 2014 A1 - Hooshmand, Nasrin A1 - O'Neil, Daniel A1 - Asiri, Abdullah M A1 - El-Sayed, Mostafa A. SN - 1089-5639 ER - TY - JOUR T1 - Hollow and Solid Metallic Nanoparticles in Sensing and in Nanocatalysis JF - Chemistry of Materials Y1 - 2013 A1 - Mahmoud, Mahmoud A. A1 - O’Neil, Daniel A1 - El-Sayed, Mostafa A. VL - 26 SN - 0897-4756 J1 - Chem Mater ER - TY - JOUR T1 - Plasmonic enhancement of photodynamic cancer therapy JF - Journal of Photochemistry and Photobiology a-Chemistry Y1 - 2013 A1 - Hayden, S. C. A1 - Austin, Lauren A1 - Near, R. D. A1 - Ozturk, R. A1 - El-Sayed, M. A. VL - 269 SN - 1010-6030 N1 - Hayden, Steven C. Austin, Lauren A. Near, Rachel D. Ozturk, Ramazan El-Sayed, Mostafa A. M3 - 10.1016/j.jphotochem.2013.06.004 ER - TY - Generic T1 - Toxicities and antitumor efficacy of tumor-targeted AuNRs in mouse model T2 - CANCER RESEARCH Y1 - 2013 A1 - Peng, Xianghong A1 - Mackey, Megan A1 - Austin, Lauren A1 - Oyelere, Adegboyega A1 - Chen, Georgia A1 - Huang, Xiaohua A1 - El-Sayed, Mostafa A. A1 - Shin, Dong M JA - CANCER RESEARCH PB - AMER ASSOC CANCER RESEARCH 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA VL - 73 SN - 0008-5472 J1 - Cancer Res. ER - TY - JOUR T1 - Antiandrogen Gold Nanoparticles Dual-Target and Overcome Treatment Resistance in Hormone-Insensitive Prostate Cancer Cells JF - Bioconjugate Chemistry Y1 - 2012 A1 - Dreaden, E. C. A1 - Gryder, B. E. A1 - Austin, Lauren A1 - Defo, B. A. T. A1 - Hayden, S. C. A1 - Pi, M. A1 - Quarles, L. D. A1 - Oyelere, A. K. A1 - El-Sayed, M. A. AB - prostate cancer is the most commonly diagnosed cancer among men in the developed countries.(1) One in six males in the U.S.(2) and one in nine males in the U.K.(3) will develop the disease at some point during their lifetime. Despite advances in prostate cancer screening, more than a quarter of a million men die from the disease every year(1) due primarily to treatment-resistance and metastasis. Colloidal nanotechnologies can provide tremendous enhancements to existing targeting/treatment strategies for prostate cancer to which malignant cells are less sensitive. Here, we show that antiandrogen gold nanoparticles-multivalent analogues of antiandrogens currently used in clinical therapy for prostate cancer-selectively engage two distinct receptors, androgen receptor (AR), a target for the treatment of prostate cancer, as well as a novel G-protein coupled receptor, GPRC6A, that is also upregulated in prostate cancer. These nanoparticles selectively accumulated in hormone-insensitive and chemotherapy resistant prostate cancer cells, bound androgen receptor with multivalent affinity, and exhibited greatly enhanced drug potency versus monovalent antiandrogens currently in clinical use Further, antiandrogen gold nanoparticles selectively stimulated GPRC6A with multivalent affinity, demonstrating that the delivery of nanoscale antiandrogens can also be facilitated by the transmembrane receptor in order to realize increasingly selective, increasingly potent therapy for treatment-resistant prostate cancers. VL - 23 SN - 1043-1802 N1 - Times Cited: 0Dreaden, Erik C. Gryder, Berkley E. Austin, Lauren A. Defo, Brice A. Tene Hayden, Steven C. Pi, Min Quarles, L. Darryl Oyelere, Adegboyega K. El-Sayed, Mostafa A. M3 - 10.1021/bc300158k ER - TY - JOUR T1 - Small Molecule-Gold Nanorod Conjugates Selectively Target and Induce Macrophage Cytotoxicity towards Breast Cancer Cells JF - Small Y1 - 2012 A1 - Dreaden, E. C. A1 - Mwakwari, S. C. A1 - Austin, Lauren A1 - Kieffer, M. J. A1 - Oyelere, A. K. A1 - El-Sayed, M. A. VL - 8 SN - 1613-6810 N1 - Times Cited: 0Dreaden, Erik C. Mwakwari, Sandra C. Austin, Lauren A. Kieffer, Matthew J. Oyelere, Adegboyega K. El-Sayed, Mostafa A. M3 - 10.1002/smll.201200333 ER - TY - JOUR T1 - Comparative study of photothermolysis of cancer cells with nuclear-targeted or cytoplasm-targeted gold nanospheres: continuous wave or pulsed lasers JF - Journal of Biomedical Optics Y1 - 2010 A1 - Huang, Xiaohua A1 - Kang, Bin A1 - Qian, Wei A1 - Mackey, M. A. A1 - Chen, P. C. A1 - Oyelere, A. K. A1 - El Sayed, I.H. A1 - El-Sayed, Mostafa A AB - We conduct a comparative study on the efficiency and cell death pathways of continuous wave (cw) and nanosecond pulsed laser photothermal cancer therapy using gold nanospheres delivered to either the cytoplasm or nucleus of cancer cells. Cytoplasm localization is achieved using arginine-glycine-aspartate peptide modified gold nanospheres, which target integrin receptors on the cell surface and are subsequently internalized by the cells. Nuclear delivery is achieved by conjugating the gold nanospheres with nuclear localization sequence peptides originating from the simian virus. Photothermal experiments show that cell death can be induced with a single pulse of a nanosecond laser more efficiently than with a cw laser. When the cw laser is applied, gold nanospheres localized in the cytoplasm are more effective in inducing cell destruction than gold nanospheres localized at the nucleus. The opposite effect is observed when the nanosecond pulsed laser is used, suggesting that plasmonic field enhancement of the nonlinear absorption processes occurs at high localization of gold nanospheres at the nucleus. Cell death pathways are further investigated via a standard apoptosis kit to show that the cell death mechanisms depend on the type of laser used. While the cw laser induces cell death via apoptosis, the nanosecond pulsed laser leads to cell necrosis. These studies add mechanistic insight to gold nanoparticle-based photothermal therapy of cancer. (c) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3486538] VL - 15 SN - 1083-3668 N1 - Huang, Xiaohua Kang, Bin Qian, Wei Mackey, Megan A. Chen, Po C. Oyelere, Adegboyega K. El-Sayed, Ivan H. El-Sayed, Mostafa A. M3 - 10.1117/1.3486538 ER - TY - JOUR T1 - Tamoxifen-Poly(ethylene glycol)-Thiol Gold Nanoparticle Conjugates: Enhanced Potency and Selective Delivery for Breast Cancer Treatment JF - Bioconjugate Chemistry Y1 - 2009 A1 - Dreaden, Erik A1 - Mwakwari, S. C. A1 - Sodji, Q. H. A1 - Oyelere, A. K. A1 - El-Sayed, Mostafa A AB - The breast cancer treatment drug tamoxifen has been widely administered for more than three decades. This small molecule competes with 17 beta-estradiol for binding to estrogen receptor, a hormone receptor upregulated in a majority of breast cancers, Subsequently initiating programmed cell death. We have synthesized a thiol-PEoylated tamoxifen derivative that can be used to selectively target and deliver plasmonic gold nanoparticles to estrogen receptor positive breast cancer cells with tip to 2.7-fold enhanced drug potency in vitro. Optical microscopy/spectroscopy, tirne-dependent dose-response data, and estrogen competition studies indicate that augmented activity is due to increased rates of intracellular tamoxifen transport by nanoparticle endocytosis, rather than by passive diffusion of the free drug. Both ligand- and receptor-dependent intracellular delivery of gold nanoparticles suggest that plasma membrane localized estrogen receptor alpha may facilitate selective uptake and retention of this and other therapeutic nanoparticle conjugates. Combined targeting selectivity and enhanced potency provides opportunities for both multimodal endocrine treatment strategies and adjunctive laser photothermal therapy. VL - 20 SN - 1043-1802 N1 - Dreaden, Erik C. Mwakwari, Sandra C. Sodji, Quaovi H. Oyelere, Adegboyega K. El-Sayed, Mostafa A. M3 - 10.1021/bc9002212 ER - TY - JOUR T1 - Peptide-conjugated gold nanorods for nuclear targeting JF - Bioconjugate Chemistry Y1 - 2007 A1 - Oyelere, A. K. A1 - Chen, P. C. A1 - Huang, Xiaohua A1 - El Sayed, I.H. A1 - El-Sayed, Mostafa A AB - Resonant electron oscillations on the surface of noble metal nanoparticles (Au, Ag, Cu) create the surface plasmon resonance (SPR) that greatly enhances the absorption and Rayleigh (Mie) scattering of light by these particles. By adjusting the size and shape of the particles from spheres to rods, the SPR absorption and scattering can be tuned from the visible to the near-infrared region (NIR) where biologic tissues are relatively transparent. Further, gold nanorods greatly enhance surface Raman scattering of adsorbed molecules. These unique properties make gold nanorods especially attractive as optical sensors for biological and medical applications. In the present work, gold nanorods are covalently conjugated with a nuclear localization signal peptide through a thioalkyl-triazole linker and incubated with an immortalized benign epithelial cell line and an oral cancer cell line. Dark field light SPR scattering images demonstrate that nanorods are located in both the cytoplasm and nucleus of both cell lines. Single cell micro-Raman spectra reveal enhanced Raman bands of the peptide as well as molecules in the cytoplasm and the nucleus. Further, the Raman spectra reveal a difference between benign and cancer cell lines. This work represents an important step toward both imaging and Raman-based intracellular biosensing with covalently linked ligand-nanorod probes. VL - 18 SN - 1043-1802 N1 - Oyelere, Adegboyega K. Chen, Po C. Huang, Xiaohua El-Sayed, Ivan H. El-Sayed, Mostafa A. M3 - 10.1021/bc070132i ER - TY - JOUR T1 - Femtosecond time-resolved two-photon photoemission studies of electron dynamics in metals JF - Progress in surface science Y1 - 1997 A1 - Petek, H. A1 - Ogawa, S. AB - Electron-hole excitation and relaxation in the bulk, at interfaces, and surfaces of solid state materials play a key role in a variety of physical and chemical phenomena that are important for surface photochemistry, particle-surface interactions, and device physics. Information on charge carrier relaxation in metals can be obtained through analysis of linewidths measured by photoemission and related techniques, which give an estimate of the upper limit for electron and hole relaxation; however, many factors can contribute to spectral broadening, thus it is difficult to extract specific information on electronic relaxation processes. With femtosecond lasers it is possible to probe directly in a time-resolved fashion the charge carrier dynamics in metals by a variety of linear and nonlinear optical techniques. Femtosecond time-resolved two-photon photoemission has attracted particularly strong interest because it incorporates many of the surface analytical capabilities of photoemission and inverse photoemission — the traditional probes for surface and bulk band structures of solid state materials — with time-resolution that is approaching the fundamental response of electrons to optical excitation. Advances in the direct measurements of electron-hole excitation, charge carrier relaxation, and dynamics of intrinsic and adsorbate induced surface states are reviewed. With femtosecond lasers it also is possible to probe a variety of coherent phenomena, and even to control the charge carrier dynamics in metals through the optical phase of the excitation light. Pioneering experiments in this new field also are discussed. PB - Elsevier VL - 56 SN - 0079-6816 UR - http://dx.doi.org/10.1016/S0079-6816(98)00002-1 CP - 4 M3 - 10.1016/S0079-6816(98)00002-1 ER -