Aggregation and Interaction of Cationic Nanoparticles on Bacterial Surfaces

TitleAggregation and Interaction of Cationic Nanoparticles on Bacterial Surfaces
Publication TypeJournal Article
Year of Publication2012
AuthorsHayden, SC, Zhao, GX, Saha, K, Phillips, RL, Li, XN, Miranda, OR, Rotello, VM, El-Sayed, MA, Schmidt-Krey, I, Bunz, UHF
JournalJournal of the American Chemical Society
Volume134
Pagination6920-6923
Date PublishedApr
ISBN Number0002-7863
Accession NumberWOS:000303139800009
Abstract

Cationic monolayer-protected gold nanoparticles (AuNPs) with sizes of 6 or 2 nm interact with the cell membranes of Escherichia coli (Gram-) and Bacillus subtilis (Gram+), resulting in the formation of strikingly distinct AuNP surface aggregation patterns or lysis depending upon the size of the AuNPs. The aggregation phenomena were investigated by transmission electron microscopy and UV-vis spectroscopy. Upon proteolytic treatment of the bacteria, the distinct aggregation patterns disappeared.

DOI10.1021/ja301167y